Russian Medical Development: News

franco wrote:The EXAR-34 exoskeleton for rehabilitation of patients with arm injuries and disorders was first developed in 2013 by a team of scientists from Russia's Volgograd Medical University led by Professor Alexander Vorobyov.
Veteran Andrei Semikashev, who had his right arm seriously injured during the special military operation in Ukraine, has been fitted with an EXAR 34 exoskeleton designed especially for him.

a couple of pieces of fabric, a few iron parts and rubber bands for wrapping money work wonders.

MOSCOW, November 9 - RIA Novosti. More than 80% of injured SVO participants return to military service after prosthetics, said Denis Kovlen, head of the department of physical and rehabilitation medicine at the Kirov Military Medical Academy.

“Over 80% of patients (from among the participants of the SVO - ed.) with traumatic amputations of limbs today, after rehabilitation and prosthetics, return to military service and continue it,” Kovlen said at a round table on the topic “Comprehensive rehabilitation of combatants and civilians, victims of the actions of the Ukrainian side during the special military operation (SVO)."

The colonel of the medical service added that this figure “neither after the Great Patriotic War, nor after Afghanistan - such figures have never been achieved.”

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In the rehabilitation and educational center operating on the basis of the Military Medical Academy named after S.M. Kirov, the head of the Department of Military Education - Deputy Head of the Main Personnel Department of the Ministry of Defense of Russia, Major General Igor Muravlyannikov presented state awards, certificates of completion of the course of additional vocational education, military ranks and orders of Courage to military personnel participating in a special military operation.

Major General Igor Muravlyannikov conveyed the words of gratitude to the servicemen from the Minister of Defense of the Russian Federation, General of the Army Sergei Shoigu for the courage, bravery and bravery shown in the performance of military duty.

The event was also attended by Alexander Novikov, Acting Deputy head of the Western branch of the FSAU Roszhilcomplex, who handed over housing documents to more than 60 servicemen.

"For military personnel who have decided to continue military service after treatment, rehabilitation and professional retraining, housing specialists have already selected and prepared places of residence in selected regions of the country," Alexander Novikov said.

The head of the Military Medical Academy, Lieutenant General of the Medical Service Yevgeny Kryukov, spoke about the program of further rehabilitation of servicemen and medical support at new places of military service: "In order to restore the lost functions, modern prostheses have been selected, manufactured and customized for each of you. A course of training in the use of them was conducted. An individual rehabilitation program has been developed for each of you, according to which, in the future, measures will be taken to maintain the prostheses and replace them if necessary."

The Minister of Defense of the Russian Federation decided to ensure the possibility of further military service for all servicemen who were injured during a special military operation (optional). The new specialties received will allow servicemen who have been injured to continue serving in new military positions in organizations of the Russian Ministry of Defense.

For reference:

For each serviceman, a military position is introduced in military commissariats, military units, institutions and organizations of the Ministry of Defense of Russia. In order to complete military service in these positions, military personnel must be trained to perform their duties.

The training programs include:

- the basic part, which provides for the study of federal legislation and regulatory legal documents in the field of state defense and mobilization work, as well as the activities of military commissariats;

- the variable part, the content of which is aimed at training in the performance of duties in the position to which the serviceman is appointed.

The final certification of military personnel is planned in the form of an interview. Upon completion of the training, the relevant documents will be issued to the persons who have successfully mastered the training program.

All teaching materials, electronic textbooks and other electronic educational resources for conducting training sessions have been developed and are ready for training.

For the implementation of educational programs, qualified teaching staff of the Military Medical Academy named after S.M. Kirov was selected from among candidates of sciences with relevant experience in training officers.

This is only one of the directions of a large-scale program of measures aimed at the social rehabilitation of wounded servicemen, approved by the Minister of Defense of the Russian Federation.

The program also provides for measures to restore health and medical rehabilitation, an individual approach to determining further service assignments and a special procedure for military service, the provision of social benefits and guarantees, as well as housing.

https://function.mil.ru/news_page/country/more.htm?id=12485182@egNews

Almost all the wounded who end up in Russian hospitals from the Northern Military District return to duty, and the mortality rate does not exceed 0.45% - this is several times less than during military conflicts of the recent past, the head of the main military clinical hospital said in an interview with Izvestia. hospital named after N.N. Burdenko Denis Davydov. Over the past year and a half, Russian military doctors have gained unique experience that no other country in the world has, he is sure. What this experience consists of, why the nature of injuries has changed, what operations are now performed right on the line of combat contact, and how modern exoprosthetics allow soldiers to remain in service - read in Izvestia’s conversation with Denis Davydov. “The means of destruction have changed a lot”

— What are the features of a special military operation compared to previous conflicts from the point of view of military medicine?

— The SVO is enormously different from the combat operations that we faced 15–20 years ago. A huge number of unmanned weapons are used that do not require the direct participation of people. The means of destruction have changed greatly, they have become more sophisticated.

We see that there are relatively few bullet wounds - about a quarter. The rest are mine-explosive and fragmentation. And the wounding elements have become different : materials that cause the greatest damage are now selected for them, and there are a lot of them.

The medical service had to learn all this very quickly and quickly adapt . It turned out, in general, quite successfully.

— We communicate at the International Forum on Surgery of Contemporary Armed Conflicts. Do Russian military doctors have anything to tell about it, based on the experience of the SVO?

— There are a number of technologies, the use of which on the battlefield 10–15 years ago we could not imagine, but today this is the practice of military doctors. First of all, this is prosthetics for the main functions of the body - the heart, lungs - directly on the line of combat contact. This technique is called extracorporeal membrane oxygenation (ECMO). Previously, damage to large vessels, the heart, and lungs inevitably led to death. Now, immediately after being wounded, almost in a trench, we can establish this system and ensure the functioning of the vital functions of the body.

We learned how to quickly immobilize a wounded person. We have rod devices that help to completely immobilize a segment of any limb in 15–20 minutes.
Operational intervention: the first ambulance train was sent to the Northern Military District zone
It will provide urgent assistance to the wounded, their recovery and evacuation.

These technologies were previously unavailable so close to the war zone. Now this makes it possible to save the lives of military personnel, quickly prepare them for transportation, provide pain relief, carry out anti-shock measures, and then transport them for further treatment.

Today we have stronger drugs: painkillers, antibiotics, drugs that help correct the psychological state of military personnel.
“Exoprosthetics have reached a new level”

— At the forum it was said that the concept of “non-transportable wounded” is disappearing. Has this problem really been solved?

— The Afghan and Chechen campaigns confirmed the experience of the Great Patriotic War: medical evacuation measures have their own laws, and they must be strictly observed.Many pathologies were considered a contraindication for transportation. Now we can say that only head wounds remain such an obstacle : you have to be careful there, and you cannot evacuate immediately after a wound or operation. As for injuries to all other segments of the body, we can safely deliver any wounded person in any condition to the stage of highly qualified medical care.


— Have you been able to reduce the mortality rate among the wounded?

— Hospital mortality now does not exceed 0.45%. And this is a colossal breakthrough for the military medical service. During the Great Patriotic War this figure was 7.5%, during the Afghan campaign - 4.4%, during the fighting in the North Caucasus - 1.1%. As for hospital mortality in the Ukrainian Armed Forces, it is many times higher.
Protective cover: a gun that heals wounds has been created in Russia
How a new development will help doctors in a combat zone

— One of the topics discussed at the forum is the increase in the proportion of wounded who return to duty after treatment. What is the dynamic here?

— During the Great Patriotic War, doctors returned about 75% of the wounded to duty. Now we manage to return 98%. The rest are forced to take a commission due to health reasons.

Previously, people with an amputated arm or leg had to leave the Armed Forces. With rare exceptions, of course: we remember them from literature - for example, the pilot Alexei Maresyev. Now this has become a common occurrence.

- What does this have to do with?

— Firstly, a new level of exoprostheses. As you pass by, you won’t even notice that the person is missing a limb or a segment of it, and it has been replaced with an exoprosthesis.And besides, we have quite a lot of positions, and there is a need for these people to continue serving in the Armed Forces and continue to help the army.

After severe injuries, people return to serve in units where staff work and training are carried out. These people have vast experience, the Ministry of Defense needs them.

Even during the rounds that we constantly conduct in the hospital, many of those who have serious injuries ask: “Can I remain in the Armed Forces? I want to continue to serve, please leave me.” Naturally, we are doing everything possible to socialize them and prevent the army from losing experienced servicemen. “Many civilian doctors came as volunteers and went to the Northern Military District zone”

— What problems do military doctors most often encounter?

“It is very difficult for us to combat the resistance of microorganisms and their growing resistance to antibiotics.

We also need technologies that make it possible to safely prosthetize the vital functions of the body.

Materials are needed that will be even more inert and will not interact with bone and soft tissue, allowing for individualization of the design. Although already now the lion's share of designs are, in fact, printed on a 3D printer and have an individual character for a particular wounded or injured person. This needs to be developed, this is the future.

— Do you feel supported by your civilian colleagues?

— After the start of the special military operation, civilian hospitals, institutes, federal and other centers called and offered help. Many doctors came as volunteers and went to the North Military District zone. And now many travel and sign contracts for military service. We were not left alone. The medical service of the Armed Forces felt the shoulder and saw that it had a huge resource to replenish its ranks with qualified specialists. And these people come not under duress or in search of some benefit, but at the behest of their hearts.
Late payment: when will doctors’ salaries be increased?
The implementation of the new remuneration system has been postponed once again

The North Atlantic Alliance, which has a huge amount of technology, people, resources, money, and capabilities, is actually fighting against us. We are confronting, essentially, alone. But time has shown that we have turned from twigs into a bundle that cannot be broken. Our level of consolidation is one of the keys to success.

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Timely provision of medical care to a wounded soldier during an armed conflict is something on which his life directly depends. But what is meant by “timely”?

Sergei Polikarpov, a volunteer military doctor, surgeon and oncologist with twenty years of experience, spoke about this in an interview with the TacticMedia channel.

As the expert put it, extreme medicine in combat conditions is primarily associated with three difficulties: a massive influx of wounded, a catastrophic lack of time to provide assistance and limited resources.

To provide the most effective first aid in the event of a mass influx of soldiers with injuries of varying severity, there is a procedure called triage. According to Polikarpov, the following categories are distinguished.

Hopeless (black) is a fighter who is silent and does not breathe. If there is a mass intake, two artificial breaths are given to him. If there is no effect, further manipulations are not carried out due to extreme time constraints.

Red – silent and breathing well. This category includes severe patients who may die in the next 10-15 minutes.

Yellow – talks, answers questions, screams and can move limbs. Helping him can be delayed for 10-15 minutes.

Green - wounded, but walks, talks and is able to help himself. At least the first one. Doctors deal with such fighters last of all.

Regarding the concept of “golden hour,” which can often be found in literature and articles on tactical medicine, as the military surgeon explained, the first peak of mortality of soldiers after being wounded, according to statistics, occurs at 40-45 minutes. Thus, the concept of “golden hour” is somewhat simplified.

The second and third peaks of mortality, as stated by the volunteer doctor, occur in the time period of 2-3 hours and after the second week, respectively.

Also during the conversation, Polikarpov spoke about one prevailing myth, which says that most wounded soldiers die from painful shock. According to the military doctor, there is no pain shock as such. A wounded soldier dies from hemorrhagic shock, that is, from blood loss.

92% of all casualties in all armed conflicts bleed to death - the expert emphasized.

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Pharmacies reduce sugar, by Polina Gritsenko for Kommersant. 12.15.2023.

An analogue of Ozempic appeared on sale despite the Danish patent

The fact that the Danish Novo Nordisk has a patent for the popular drug for controlling glucose levels “Ozempic” did not prevent the appearance of a local analogue of the drug in pharmacies. Sales of “Quincenta” released by Promomed began in several chains in Moscow and St. Petersburg. Only Novo Nordisk itself can ban the circulation of generics, but it will probably be more profitable for the company to reach an agreement with manufacturers of analogues, experts say.

The Promomed company's drug for controlling sugar levels, semaglutide, under the brand name "Quincenta", appeared in the pharmacies "Zdorov.ru" and "Fialka" in Moscow and St. Petersburg, Kommersant discovered on the online display windows of these pharmacies. According to AptekaMos.ru, “Quincenta” can also be purchased at REDapteka in Moscow and “People’s Pharmacy” in St. Petersburg. The cost of "Quincenta" is from 5.65 thousand to 5.7 thousand rubles. per package.

“Quincenta” is a generic version of the popular drug “Ozempic” registered in October by the Danish Novo Nordisk. It is indicated for controlling glucose levels in diabetics, but off-label in Russia it is also used for weight loss. In 2022, sales of Ozempic worldwide increased by 77%, to DKK 59.75 billion (RUB 825.3 billion), Novo Nordisk reported. The company must stop supplying Ozempic to Russia by the end of this year; now the drug is sold only with preferential prescriptions.

"Quincenta" went on sale despite the presence of a patent for the original "Ozempic" in the Russian Federation, which is valid until 2035. Promomed told Kommersant that they are in correspondence with Novo Nordisk and, in parallel with providing patients with vital drugs, are resolving legal aspects. Novo Nordisk declined to comment.

Another analogue of semaglutide under the brand name Semavica is being prepared for sale by Geropharm. The first three series of this drug were put into circulation on December 11, according to data from Roszdravnadzor. “Geropharm” in the fall turned to the government with a request for a compulsory license, said the general director and co-owner of the company Pyotr Rodionov. The company offered Novo Nordisk to start producing Ozempic at its facilities, but did not receive a response. Geropharm told Kommersant that Semavik will go on sale after the government’s decision on compulsory licensing.

The Ministry of Industry and Trade told Kommersant that the mechanism for issuing a compulsory license “requires careful application” to maintain a balance of interests of manufacturers and patients.

As a representative of the Ministry of Industry and Trade recalled, companies have the right to demand a compulsory license through the court, citing insufficient use of the patent. According to the file of arbitration cases, as of December 15, no such applications had been received.

As part of the government order, analogues of semaglutide have been purchased since November, as follows from the information on the government procurement website. According to Kommersant’s calculations, by December 14, the regions had signed contracts for the supply of Semavik or Quicenta for 147.2 million rubles. Contracts for RUB 52.9 million. are at the signing stage. Some agreements limit delivery to the end of 2023. There are no completed contracts yet.

Alexey Mikhailov, head of patent practice at the Patentus bureau, says that only the manufacturer of the original medicine, if it is under patent protection, can obtain a ban on the sale of a generic through the court. DSM Group CEO Sergei Shulyak points out that if Novo Nordisk goes to court, it may receive a counterclaim for compulsory licensing due to non-use of the patent. In his opinion, it may be more profitable for the Danish company to negotiate with Promomed and Geropharm on the sale of generics under certain conditions.

https://www.kommersant.ru/doc/6409426

This drug is a quick fix. People are too lazy to reduce their glucose (including starches) and fructose intake and do intermittent fasting. The
latter would do wonders for their health. The long term effects of the pharmaceutical are unknown and given the track record not likely to
be good.

kvs wrote:This drug is a quick fix.  People are too lazy to reduce their glucose (including starches) and fructose intake and do intermittent fasting.   The latter would do wonders for their health.   The long term effects of the pharmaceutical are unknown and given the track record not likely to be good.

No amount of fasting can cure diabetes. Sure it will lower blood sugar somewhat but people with advanced diabetes cannot have a normal glicemic level and maintain a normal weight with fasting alone.

Try seeing pictures of terminal cases of diabetes before injectable insulin was invented. Advanced diabetes patients lose weight as the body becomes unable to use the glucose in the blood. Then they just die without treatment.

As for negative long term effects of semaglutide it is known that it can cause cancer in some rare cases. Much more common side effects are nausea and vomiting.

Russian Ministry of Health registers the first drug created from a cellular material, 12.15.2023.

MOSCOW (Sputnik) — The Russian Ministry of Health has registered the first biomedical cellular product, the drug Izitens, which is used in the treatment of knee joint problems, the press service of the Russian entity reported.
I
"The Russian Ministry of Health has registered the first biomedical cellular product. The Izitens drug is the first industrial experience in the application of the transplantation technology of a cellular product," the statement said.

The drug, which includes human cartilage cells, is designed to cure cartilage problems of the knee joint in patients over the age of 18, the ministry said.

Biomedical cell products represent cultured human cells that are widely used in regenerative medicine. The healing properties of such products are formed in the process of working with the biomaterial, obtained from a patient or a donor.

Yandex Translate from Spanish

https://sputniknews.lat/20231215/el-ministerio-de-salud-de-rusia-registra-el-primer-farmaco-creado-de-un-material-celular-1146610529.html

The world's first operation to replace a soft tissue injury by in situ bioprinting directly into a wound defect was performed by surgeons of the Main Military Clinical Hospital (GVKG) named after Academician N. N. Burdenko, the press service of the National Research Technological University "MISIS" (NUST MISIS) reported on December 26.

The operation used a bioprinter developed by NUST MISIS scientists and 3D Bioprinting Solutions, a pioneer of Russian bioprinting. The bioprinter device contains a bioprinting system, computer vision and a robotic arm that supplies biopolymer to the wound.

The trajectory of this robot after automatic scanning of the damage site was programmed by a MISIS specialist. Next, the bone marrow cells taken from the patient by the doctor were "tucked" into a bioprinter, and the robot carried out the bioprinting without human participation.

https://rossaprimavera.ru/news/5bb68e3e

The Ministry of Health stated that Russian medicines can replace foreign ones, 02.02.2024.

Murashko: if there are problems with foreign medicines, they will be replaced by Russian ones.

MOSCOW, February 2 – RIA Novosti. Russia has significant competencies in pharmaceuticals, and if any foreign company leaves the Russian market, the government may decide to launch its own production of a similar drug, Health Minister Mikhail Murashko said in an interview with RIA Novosti.

“We understand that if we do not violate international law, including patent law, when work is carried out as planned and as a partnership, but the company decides to act differently, then the government of the Russian Federation already has practice when We make our own decisions in the interests of the population and, accordingly, production,” he said.

The minister recalled that, according to global estimates, Russia is among the leaders in the pharmaceutical field. All countries understand this perfectly well, and therefore companies realize that it is inappropriate to leave the Russian market, Murashko concluded.

As President Vladimir Putin noted this week , Russia now produces 75 percent of vitally needed medicines through its own production. But this is not enough, we need to support science, technology development, the domestic market and production, the head of state emphasized.

https://ria.ru/20240202/lekarstva-1924939749.html

GarryB wrote:
Fat people just have to learn it is OK to be hungry and if you get hungry but you don't eat... you don't keep getting hungrier and hungrier until you die... eventually the feeling of hunger goes away and your body uses your fat reserves for the energy it needed.

Most people do not know that their hunger is a hormone-mediated conditioned reflex and not actual need for food. The hormone ghrelin initiates the hunger signals. It happens
typically three times a day around the time when people usually eat. If you do substantial fasting (e.g. alternate day fasting) you can reset this signalling pattern and not be
hungry on some clock. You can transition to one meal a day or any other pattern. You can continue alternate day fasting without any harm. Fasting enables the body
to fix itself, this includes stem cell release and clean up of damaged proteins and structures such as mitochondria. The fasting after dinner and during sleep is not enough.
Intermittent fasting combined with a low carb diet is the best anti-inflammatory regimen possible. People who eat the standard high carb diet every day are perpetually
low-grade inflamed. It is impressive how such a state does not lead to mortality by the time people reach their 40s. But it does produce the heart disease, diabetes,
Alzheimer's and even cancer that you see in people over 50.

The sick thing is that governments and medical associations do not inform the public how to avoid becoming metabolic syndrome victims through the most effective means,
diet (i.e. real diet advice not food pyramid BS) and physical activity. Instead they push extortion priced pharmaceuticals. One of my close relatives is being given high
carb meals at the hospital even though they are a diabetic. Don't expect proper treatment from the system.

PUTIN: THE RF HAS SIGNIFICANT ACHIEVEMENTS IN MEDICINE, BUT WE NEED TO MOVE FURTHER, INCREASE SELF-SUFFICIENCY, AND BECOME GLOBAL LEADERS.

Russia is close to creating cancer vaccines, Putin said.
Putin expressed hope that the use of cancer vaccines will soon begin.

East African country opens medical lab equipped by Russia – envoy, 03.13.2024.

Moscow has supplied reagents for research in Burundi, Valery Mikhailov has said.

Burundi has launched operations at a specialist infectious disease research laboratory fully outfitted with Russian equipment, Moscow’s ambassador to Burundi, Valery Mikhailov, told TASS on Wednesday.

Specialists in Burundi now have the opportunity to recognize and identify infectious diseases, even those that are “highly dangerous,” Mikhailov added.

According to the envoy, Moscow has supplied laboratory reagents that can be used to treat various forms of hemorrhagic fever, leptospirosis, and other dangerous infectious diseases.

“In February, a fully equipped research laboratory supplied by Russia was opened at the National Institute of Public Health,” the diplomat said. He noted that the agreement to supply and stock the lab had been reached during the Russia-Africa Summit last summer, when bilateral deals deals were signed on energy, healthcare, education, labor, and justice.

In August, the World Health Organization released a report stating that Burundi has a “high burden of communicable and non-communicable disease… with the latter making up 37% of deaths in 2019.” Although it made strides in improving child survival rates from 2015 to 2021, it has not achieved the Sustainable Development Goal targets.

In November last year, a team of virologists and military personnel from the Russian Nuclear, Chemical, and Biological Protection Troops arrived in Burkina Faso to set up a mobile laboratory for dengue fever screening. Moscow dispatched specialists after the military government of the West African country stated that since January of last year, more than 200 people died as a result of the mosquito-borne epidemic, mainly in the capital, Ouagadougou and Bobo-Dioulasso.

https://www.rt.com/africa/594210-burundi-medical-laboratory-russian-equipment/

Cancer vaccines ready within three years – Russian scientist, 03.21.2024.

Most remaining obstacles appear to be regulatory, according to Vasily Lazarev of Russia’s Federal Medical-Biological Agency.

Russian medical researchers could be able to roll out oncological vaccines within the next couple of years, given adequate funding and support from lawmakers, a high-ranking official at the Federal Medical-Biological Agency (FMBA) said on Thursday.

The comments come after President Vladimir Putin said last month that the country was “one step away” from developing vaccines against cancer.

“If financial support is provided, I think that in two or three years existing organizations will be able to put oncology vaccines into practice,” Vasily Lazarev, deputy director of the Lopukhin Federal Scientific and Clinical Center for Physical and Chemical Medicine, told the outlet RTVI.

Domestic private investors will also be attracted to the technology “after regulatory pressure eases,” he added.

Lazarev did not bring up any medical or technological challenges, choosing instead to highlight the legal constraints facing vaccine development.

“I don’t know how quickly by-laws will be developed, it could take a year to resolve all the regulatory issues,” he said. “We have the tools, the production facilities, I think it’s not difficult to organize.”

Amendments proposed by the FMBA, which would allow for the production and use of “variable composition” medication, will go into effect in September. They also require the drugs to be produced at the same institution that holds the patent, however.

“Organizing such production at home will be quite expensive, although it is feasible,” Lazarev said. “Most likely, these will be regional centers and maybe specialized oncological institutions.”

There are currently only a handful of facilities that could handle the production requirements, such as the Blokhin Cancer Center or the FMBA’s Federal Center for Brain and Neurotechnology, both located in Moscow.

Variable-composition neoantigens, which vaccine developers have focused on, don’t quite fit the current Russian legal framework and could not be used in treatments at all until very recently.

Putin revealed the development of cancer vaccines at the Future Technologies Forum in Moscow last month. The Russian president mentioned them among the developing medical technologies that he described as approaching science fiction.

https://www.rt.com/russia/594630-cancer-vaccine--development-timeline/

"The Russian Ministry of Health has registered the world's first and first-in-class targeted drug for the treatment of Bekhterev's disease. According to the results of clinical trials, it has shown a high profile of efficacy and safety," the report says.

https://ria.ru/20240425/preparat-1942182856.html